Results
| PMID | 18053993 |
| Gene Name | VEGFA |
| Condition | Endometriosis (ovarian) |
| Association |
Associated |
| Population size | 50 |
| Population details | 50 patients with ovarian endometriotic cysts |
| Sex | Female |
| Associated genes | Cox-2, VEGF |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2008 Oct;90(4):988-93. Epub 2007 Dec 3. Ceyhan, Seyit Temel| Onguru, Onder| Baser, Iskender| Gunhan, Omer Department of Obstetrics and Gynecology, Gulhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey. stceyhan@gata.edu.tr OBJECTIVE: To investigate the expression of cyclooxygenase-2 (Cox-2) and vascular endothelial growth factor (VEGF) in ovarian endometriotic cysts and assess their relation with angiogenesis. DESIGN: Experimental clinical study. SETTING: University hospital. PATIENT(S): Fifty patients with ovarian endometriotic cysts. INTERVENTION(S): Surgical excision of 50 ovarian endometriotic cysts. MAIN OUTCOME MEASURE(S): Microvessel density and the expression of Cox-2 and VEGF were analyzed immunohistochemically. RESULT(S): Cyclooxygenase-2 immunoreactivity was mainly cytoplasmic in glandular epithelial cells in all of the ovarian endometriotic cysts, with low expression in 12 cases (24%), moderate expression in 21 (42%), and high expression in 17 (34%). Vascular endothelial growth factor immunoreactivity was mainly cytoplasmic in stromal cells in 46 (92%) of the ovarian endometriotic cysts, with low expression in 12 cases (24%), moderate expression in 18 (36%), and high expression in 16 (32%). No immunoreactivity was present in 4 cases (8%). Both Cox-2 (r = 0.728) and VEGF (r = 0.670) were closely, statistically significantly related with microvessel density in ovarian endometriotic cysts. Cyclooxygenase-2 and VEGF also were highly statistically significantly correlated (r = 0.777) with each other. CONCLUSION(S): We observed Cox-2 expression mostly in glandular epithelial cells of ovarian endometriotic cysts, whereas VEGF expression was observed mainly in stromal cells. Cyclooxygenase-2 and VEGF were closely correlated with each other, and both of them appear to play a role in the angiogenesis of ovarian endometriosis. Mesh Terms: Adult| Cyclooxygenase 2/*metabolism| Endometriosis/*metabolism| Female| Humans| Neovascularization, Pathologic/*metabolism| Ovarian Cysts/*metabolism| Ovary/*metabolism| Vascular Endothelial Growth Factor A/*metabolism|DA 2008/11/15 09:00 |
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